[HTML][HTML] Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes
F Li, A Dluzewski, AM Coley, A Thomas, L Tilley… - Journal of Biological …, 2002 - ASBMB
Apical membrane antigen-1 (AMA1) is a transmembrane protein present on the surface of
merozoites that is thought to be involved in the process of parasite invasion of host
erythrocytes. Although it is the target of a natural immune response that can inhibit invasion,
little is known about the molecular mechanisms by which AMA1 facilitates the invasion
process. In an attempt to identify peptides that specifically interact with and block the function
of AMA1, a random peptide library displayed on the surface of filamentous phage was …
merozoites that is thought to be involved in the process of parasite invasion of host
erythrocytes. Although it is the target of a natural immune response that can inhibit invasion,
little is known about the molecular mechanisms by which AMA1 facilitates the invasion
process. In an attempt to identify peptides that specifically interact with and block the function
of AMA1, a random peptide library displayed on the surface of filamentous phage was …
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